Thrombolytics

• Non–fibrin-specific agents
• Strepotkinase
• AMI, PE, DVT, arterial thrombosis, and occluded arteriovenous cannulae
• Fibrin-specific agents
• Alteplase (tPA)
• FDA approved - AMI, ischemic stroke, PE, occluded central venous access devices
• Reteplase (r-PA)
• FDA approved - AMI
• Tenecteplase
• FDA approved - AMI

Jefferson tPA protocol for ischemic stroke

Thrombolytic Dosing



Source: http://www.uspharmacist.com/CMSImagesContent/2011/2/USP1102-HSThrombo-T1.gif